β-Nicotinamide adenine dinucleotide NAD Powder

Nicotinamide adenine dinucleotide (abbreviated as NAD), also known as diphosphate pyridine nucleotide (abbreviated as DPN), or co-dehydrogenase I or coenzyme I. There are two states of oxidized form (NAD+) and reduced form (NADH) in mammals. The oxidized form (NAD+) has a maximum UV absorption spectrum at 260nm. Through various deaminase enzymes, it accepts a hydrogen atom from the substrate and An electron becomes a reduced form (NADH) and has a maximum absorption at 340nm. β-Nicotinamide adenine dinucleotide serves as a coenzyme in redox reactions, as a donor of the ADP ribose moiety in the ADP ribosylation reaction, and as a precursor of the second messenger molecule cyclic ADP ribose. Beta-nicotinamide adenine dinucleotide also acts as a substrate for bacterial DNA ligase and a group of enzymes called sirtuins, which use NAD+ to remove acetyl groups from proteins.

NAD is a biological substance, which can also be written as NAD+ nicotinamide adenine dinucleotide, referred to as oxidized coenzyme I. It is a kind of electron transfer. It is a coenzyme of many dehydrogenases in the body. It connects the tricarboxylic acid cycle and the respiratory chain. Its function is to transfer the hydrogen taken off during metabolism to flavoprotein. NADH or more accurately NADH with H+ is its reduced form. Research shows that the Slc12a8 protein transports nicotinamide mononucleotide (NMN) directly into cells with the help of sodium ions, where it quickly functions for NAD production. When NAD levels decrease, cells also enhance the expression of the Slc12a8 gene, increasing their ability to transport NMN.

Experimental results show that taking nicotinamide ribose can increase the content of nicotinamide adenine dinucleotide (NAD+) in the human body by 60%. NAD+ is an indispensable substance for activating acetylase and will decrease with age.

Anti-aging: NAD+powder can activate SIRT1 protein, delay cell aging and DNA damage, and reduce the occurrence of age-related diseases.

Enhance energy: NAD participates in the energy production process of cell mitochondria, improves cell energy levels, and enhances physical strength and endurance.

Promote cell repair: It can activate PARP enzyme, repair DNA damage, and promote cell repair and regeneration.

Improve cognitive function: By activating SIRT3 protein, it improves brain cell function and enhances memory and learning ability.

Regulate metabolism: Participate in a variety of metabolic pathways, such as glycolysis, fatty acid oxidation, etc., regulate energy metabolism balance, help lose weight and control blood sugar levels.

Assists DNA repair One of the causes of aging is DNA damage. Your white hair, ovarian and other organ decline, are all related to DNA damage. Staying up late and being stressed will aggravate DNA damage.

Studies have found that nicotinamide adenine dinucleotide helps activate the PARP1 gene, which acts as a first responder to detect DNA damage and then promotes the selection of repair pathways. PARP1 leads to the decompression of chromatin structure through ADP ribosylation of histones , as well as interact with and modify a variety of DNA repair factors to improve repair efficiency), thereby repairing DNA damage and promoting the triggering of metabolic shifts.

In summary, NAD+ can directly and indirectly affect many key cellular functions, including metabolic pathways, DNA repair, chromatin remodeling, cellular senescence, immune cell function, etc., thereby slowing down the human aging process.