Osthole
Product Name:Osthole
Source:Cnidium monnieri fruit
CAS NO.:484-12-8
Molecular Formula:C15H16O3
Molecular Weight:244.29
Appearance: The low content such as 35% and 50% is yellow-green powder, while the high content is white needle-like crystalline powder.
Solubility: Soluble in alkali solution, methanol, ethanol, chloroform, acetone, ethyl acetate and boiling petroleum ether, etc., insoluble in water and petroleum ether, mp.83℃～84℃, bp.145℃～150℃.
What is Osthole?
The main components of osthole: Cnidoma fruit contains 1.3% volatile oil. Its main components are l-pinene, l-camphene, bornyl isovalerate, isoborneol etc. It also contains Osthole, Isopimpi-nelline, Bergapten, Archangelicin, Columbia aglycone (Columbia-netin), and caffeine. Columbianadin, o-Acetylcolumbianetin, o-Isovaleryl columbianetin, Cnidiadin, Cnidimine (Edultin) ) and other coumarin ingredients.
Osthole Function
Anti-pathogenic microorganism effect: Cnidium monnieri has inhibitory effects on Epidermophyton floccosum, Microsporum gypsum, and Microsporum woolly in vitro. Newcastle virus cultured in chicken embryos can extend the life of chicken embryos by 6 hours. Cnidogenide extract (1:2) in culture medium at 37°C killed all Trichomonas vaginalis in 17.5 minutes. Observed under a microscope, when osthole was instilled, Trichomonas immediately stopped moving, while the control group could move for 1 hour. hours or more. However, some people have observed that Cnidium monnieri extract has no effect on killing Trichomonas vaginalis in vitro. However, the Cnidoma monnieri leachate with a concentration of 1g/ml has an inhibitory effect on Epidermophyton floccosum and Microsaccharomyces licheniformis when diluted in the culture medium at a factor of 1:10. At 1:20, it has an inhibitory effect on Microsporum ovis. It has a significant inhibitory effect on influenza viruses. Cnidium powder can attract larvae and flies.
Sex hormone-like effects: Continuous subcutaneous injection of Cnidoma monnieri ethanol extract into mice for 32 days can prolong the estrous period, shorten the interestrus period, cause estrus in castrated mice, and increase the weight of the ovaries and uterus. The method of increasing the weight of the prostate, seminal vesicles, and levator ani muscles (mice) proved that Cnidium monnieri extract has androgen-like effects. It has no corrosive effect on rabbit vaginal mucosa.
Killing effect on sperm: Mix Cnidium monnieri extract powder with physiological saline into 20%, 25%, 30%, 35%, 40% suspension, place at room temperature for 48 hours, and centrifuge at 200 rpm After 10 minutes, the supernatant was filtered and stored at 4°C. Observing the spermicidal effect of the medicine, it can be seen that the spermicidal effect increases with the increase of the concentration of the medicine. The minimum effective concentration to inhibit human sperm within 20 seconds is 30%. Each milliliter of semen is mixed with different doses of Cnidoma monnieri extract powder. The lowest effective dose for inhibiting sperm motility is 250-300 mg. Experiments have shown that Cnidium monnieri may become a vaginal contraceptive.
Anti-allergic effect: Animal experiments show that the acetone extract of Cnidium monnieri has a strong antihistamine effect. It can significantly antagonize the intestinal muscle contraction caused by histamine, chronic reactive substances and 2% egg white. Osthole was administered to mice and had a strong inhibitory effect on passive skin allergic reactions in mice. Intraperitoneal injection of osthole can inhibit degranulation of peritoneal mast cells in rats caused by trichosanthin.
Effects on the respiratory system: Studies have shown that Cnidol has a strong bronchodilatory effect. Cnidol can increase pulmonary perfusion in guinea pigs, and its effect is stronger than aminophylline. Administration of total coumarins from Cnidoma monnieri to guinea pigs can prolong asthma attacks in guinea pigs caused by histamine phosphate and acetylcholine chloride. In vitro experiments have shown that total coumarins from Cnidium monnieri have a strong antagonistic effect on histamine-induced tracheal contraction in isolated guinea pigs. The above effects can be blocked by propranolol without affecting the heart rate and blood pressure of anesthetized animals, suggesting that total coumarins from Cnidium monnieri may selectively excite β2 receptors on bronchial smooth muscle, producing antispasmodic and antiasthmatic effects. The total coumarins from Cnidium monnieri were administered to mice by gavage, which can significantly increase the excretion of phenol red, indicating that this product has a strong expectorant effect.
Local anesthesia: Cnidium monnieri decoction and alcohol precipitate (100%) can completely block the generation of action potentials in the isolated sciatic nerve of toads. Its intensity is the same as that of 10% procaine. Normal conduction function can be restored after stopping the drug. ; It has an infiltration anesthesia effect on guinea pigs, which can be enhanced by epinephrine hydrochloride, but the local anesthesia effect is shorter than 10% procaine; it has a spinal anesthesia effect on rabbits, but has no surface anesthesia effect on the rabbit cornea ．
Anti-mutagenic effect: Experiments show that the water-soluble extract of Cnidium monnieri has strong anti-mutagenic properties. It has a strong anti-mutagenic effect on the cancer-inducing agent aflatoxin B1; it can reduce the frequency of SCE (sister chromosome exchange in isolated cells) induced by Zhengdingmycin and cyclophosphamide; it has a strong anti-mutagenic effect on mice induced by cyclophosphamide. Chromosomal aberrations and micronucleus occurrence in bone marrow cells have antagonistic effects, and as the dose of Cnidium monnieri extract increases, the aberration rate and micronucleus cell rate gradually decrease.
Osthole binifit
Cnidium monnieri is a traditional Chinese medicine. It is the fruit of the plant Cnidium of the Apiaceae family. It has the functions of drying dampness, killing insects, warming the kidneys and strengthening yang, dispelling wind and relieving itching (relieving itching by removing wind evil that invades the skin surface). . It is mostly used to treat cold-damp vaginal discharge, vaginal wetness and itching, eczema, scabies, dampness and lumbago, kidney deficiency and impotence, and uterine cold infertility. It is also currently used clinically to treat eczema, scabies, vaginitis, cervicitis, rheumatoid arthritis, rheumatoid arthritis, male sexual dysfunction, infertility and other diseases. There are currently no reports of adverse reactions to Cnidium monnieri. Those with damp and hot lower burnt, easily moved fire phase, and unstable Jing Guan should not take Cnidium monnieri. It is recommended to consult a professional Chinese medicine doctor before taking Cnidium monnieri, and do not take medicine by yourself.
Osthole Application
Treatment of peripheral neuritis, treatment of yellow water sores, treatment of tinea pedis infection, treatment of male infertility, treatment of eczema, treatment of vulvar pruritus, treatment of vulvar lichen, treatment of white lesions of the vulva, treatment of vulvar condyloma in women, treatment of fungal vaginitis, treatment of trichomonas vaginitis, treatment of bronchial tubes in children asthma.