98% Genistein Powder

Genistein, also known as 5,7,4-trihydroxyisoflavone, genistein, genistein, etc., is mainly derived from soybeans, clover, kudzu root, sophora japonica, genistein (gorse) and Active ingredients extracted from leguminous plants such as broad beans root. Genistein, the main component of soy isoflavones, has a structure similar to estrogen, so it is called "phytoestrogens". Since estrogen deficiency is an important cause of osteoporosis in postmenopausal women, genistein is one of the current research hotspots of anti-osteoporosis botanical drugs. The "Latest Guidelines" of the National Osteoporosis Foundation (NOF) pointed out that genistein is very beneficial to the bone health of postmenopausal women. It is the only plant active ingredient that the FDA considers safe but still needs more anti-osteoporosis clinical data. .

Many studies have shown that genistein can alleviate inflammation, alter intestinal flora, and improve epithelial barrier function in several animal models of intestinal diseases. Furthermore, genistein is known to have beneficial effects on age-related diseases such as neurodegenerative and cardiovascular diseases, bone loss, and skin aging, but its precise role in aging intestinal homeostasis remains to be elucidated.

As a "phytoestrogen", genistein can promote the proliferation, differentiation and mineralization of bone formation functions of osteoblasts, and can also inhibit the bone resorption process of osteoclasts. It has a variety of anti-osteoporosis molecular mechanisms.

The anti-osteoporosis effect of genistein involves mechanisms such as promoting the proliferation, differentiation and bone formation of osteoblasts and inhibiting the proliferation, differentiation and bone resorption of osteoclasts. In addition, genistein, as a "phytoestrogen", binds to estrogen receptors (ER) in the body to produce a regulatory effect. It is an ideal selective estrogen receptor regulating activity. of natural compounds.

Genistein can inhibit osteoclastic bone resorption through the NF-κB pathway. In addition, genistein can mediate intracellular calcium ion signaling pathways and inhibit protein kinases and tyrosine kinases, thereby causing osteoclast apoptosis and thereby inhibiting bone resorption. Osteoclast formation can also be reduced by inhibiting the activity of DNA topoisomerase II.

As a "phytoestrogen", genistein has a similar structure to endogenous estrogens (such as 17β-Estradiol) and has estrogen-like effects. There are two types of estrogen receptors in the human body, namely estrogen receptor ɑ (REɑ) and estrogen receptor β (REβ). In addition to the reproductive system, ER is present on osteoblasts, osteoclasts, and bone marrow stromal cells. Among them, ERɑ is mainly expressed in diaphyseal osteocytes, and ERβ is extremely lowly expressed in diaphyseal osteocytes; ERβ is significantly expressed in cancellous bone osteocytes, and is also expressed in the nucleus and cytoplasm of osteoclasts. The affinity of genistein to ERβ is greater than that to ERα, but its main receptor for exerting anti-osteoporosis effect is ERα, so ERα is the main receptor subtype for genistein to exert bone protective effect. In addition, phytoestrogens have a bidirectional regulatory effect when combined with ER in the body, that is, they show estrogen-like or anti-estrogen effects (promoting at low concentrations and inhibiting at high concentrations) under different circumstances. It is an ideal estrogen replacement drug.

Genistein plays a very important role in reducing the incidence of cardiovascular disease. Low-density lipoprotein cholesterol in the blood is high and is easily oxidized, which can cause atherosclerosis. Genistein can effectively reduce cholesterol through antioxidant effects, inhibit the oxidation of low-density lipoprotein cholesterol (LDL), and reduce LDL in the blood. Keep the level at a low level, improve the abnormal peroxidation status in the body caused by high fat, and alleviate the peroxidative damage to the body. Genistein can upregulate LDL receptors and increase LDL receptor activity, thereby promoting cholesterol clearance. Genistein also inhibits the proliferation of smooth muscle cells, angiogenesis and cell adhesion, thereby reducing the incidence of cardiovascular disease.